Sentence examples for microenvironment is critical from inspiring English sources

Extracellular matrix (ECM) microenvironment is critical for the viability, stemness, and differentiation of stem cells.

The tumour microenvironment is critical to both the initiation and maintenance of tumorigenesis.

Mimicking the native tissue microenvironment is critical for effective tissue regeneration.

Aside from NF1 loss in specific cell populations (e.g. Schwann cells) an NF1 heterozygous microenvironment is critical for the formation of NF1 tumours like plexiform neurofibromas or optic gliomas3,4,5.

The larger message, says her UCSF colleague Zena Werb, is that "you can't look at the tumor cell in isolation," and that dissecting a cancer's microenvironment is critical to understanding what drives it.

It is well documented that gene function and relevance varies remarkably when compared in vivo and in vitro, and studying the effect of defined genetic alterations on therapeutic response in either native or damaged tumor microenvironment is critical for effective drug development, personalized anticancer regimes, and optimal design of combination therapies.

Factors such as tumor architecture, interactions among cancer cells and between cancer and stromal cells, and an acidic tumor microenvironment are critical characteristics observed in patient-derived cancer xenograft models and in the clinic.

Poorly functional osteoclasts in double-deficient mice suggest that ITAM-containing adapter-associated receptors and their ligands present in the microenvironment are critical for osteoclast differentiation in normal bone remodeling.

These findings support the concept that cell spreading/mechanical force, along with tissue microenvironment, are critical for dermal fibroblast function.

These results suggest that the presence of T cells within the 4T1 tumor microenvironment was critical but not solely responsible for establishing an inflammatory 4T1 tumor microenvironment in mammary tissue.

Interactions between myeloma cells and cells of the bone marrow microenvironment are critical for myeloma growth and survival and for the development of the osteolytic bone disease [ 13, 14].