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Typically, secondary tumor formation within the bone microenvironment is considered a function of bone resorption because the degrading bone mineral matrix releases bioactive ions and growth factors critical to the proliferation of both normal and transformed cells [4], [11], [36], [37].
The inability to overcome the immunosuppressive behavior of the tumor microenvironment is considered a major hurdle in the development of effective immunotherapies.
* For the purpose of estimating exposure, a microenvironment is considered a spatial compartment where an individual spends time and exposure can be characterized during that time.
Among other factors like immunosurveillance, switches of transcriptional pathways and programmes, the local microenvironment is considered a critical determinant of metastatic outgrowth.
For the purpose of estimating exposure, a microenvironment is considered a spatial compartment where an individual spends a certain period of time and exposure can be characterized during that time period.
Thus, the disturbed oxidant/antioxidant balance as the AGEs accumulation within the chronic wound microenvironment is considered a major factor, which amplifies the unrestrained and persistent inflammatory, toxic, and catabolic state of nonhealing wounds [ 96].
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The hypoxic microenvironment was considered to be one of the major factors contributing to GPI overexpression.
Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression.
It is released by both stromal cells and tumor-associated macrophages in the tumor microenvironment, and is considered to have pro-angiogenic and pro-malignant effects [ 10].
Hypoxia is a key change of the tumor microenvironment after irradiation and is considered as one of the central factors leading to resistance of radiotherapy.
The crosstalk between the tumor microenvironment and prostate cancer cells is considered to be critical for the progression of cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com