These cells, and others, represent a microenvironment that is conducive to the growth and development of HSCs.
A microenvironment that is conducive to stem cell self-renewal is referred to as a stem cell niche [ 16, 68].
Hydrated PCM provides the microenvironment that is conducive to adjustments in cell shape and epithelial architecture during dynamic morphogenetic processes like wound healing, embryonic development, inflammation, and cancer [ 198].
TGF α -EGFR signaling in colon cancer cells creates a microenvironment that is conducive for metastasis, providing a rationale for efforts to inhibit EGFR signaling in TGF α -positive cancers.
These factors could represent a constellation of heritable characteristics that promote transformation events and/or facilitate the establishment of a microenvironment that is conducive for survival of malignant blood vessel-forming cells.
We postulate that an intricate interaction between TGF- β and IGF-I signaling in prostate CAF cells has created a unique microenvironment which is conducive for cancer development and progression in the adjacent epithelial cells.
The emerging solution to this conundrum, at least in some cases, is that specific protein-nucleic acid or protein-protein interactions initiate the assembly of membrane-less organelles, which then create a microenvironment that is conducive to phase separation of additional components (Fig. 2).
These data suggest that PBT2 may foster a brain microenvironment that is conducive to neuronal health, which may help overcome age- or disease-related losses in neurogenesis (Lazarov et al., 2010) and cell death (Stranahan et al., 2012) and ultimately cognition.
In addition, to determine whether EA results in microenvironment change that is conducive to NSC proliferation in the dentate gyrus (DG), we observed the effects of microdialysates from the DG of CUS rats with/without EA treatment on the proliferation of NSCs in vitro.
Thus either there is a modest influx of NK cells from the liver, or the tumour microenvironment is more conducive to recruitment of NKG2Ahi NK cells.
