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Koti, M. et al. A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.
In many cancers, mast cell density (MCD) in the tumor microenvironment is associated with tumor progression and, to a greater extent, angiogenesis.
The authors also showed that dense stroma in the tumour microenvironment is associated with better outcomes in pancreatic cancer patients.
The composition of the tumor microenvironment is associated with a patient's prognosis and can be therapeutically targeted.
However, tumor vasculature is structurally abnormal and functionally inefficient, and the resultant hypoxic microenvironment is associated with tumor progression and resistance to therapies.
In contrast to the systemic response, local infiltration of inflammatory cells in the tumour microenvironment is associated with improved survival in patients with colorectal cancer.
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The increased numbers of T cells in the tumor microenvironment were associated with a reduction in the numbers of MDSCs in silibinin-treated immunocompetent mice.
EGF and TGF α-enriched bone microenvironment are associated with stimulation of osteoclastogenesis through increased production of RANKL by bone stromal cells [ 98, 99].
It has also been reported that CCL17 and CCL22 chemokines within the tumour microenvironment are associated with the accumulation of regulatory T cells (Tregs) in GC (Mizukami et al. 2008).
Of the three genes found with significantly augmented expression in cocultures, two were proteases (MMP1 and MMP9), whose elevated expressions in the tumor microenvironment are associated with tumor cell invasion through increased degradation of ECM components.
The data suggest that changes in mesenchymal cells in the HNSCC microenvironment are associated with increased levels of colXI α1, a finding that is at odds with Halsted et al (2008), who found that colXI α1 was downregulated in stroma surrounding breast cancer.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
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