The tumour microenvironment is a highly complex and dynamic tissue.
Reconstitution of the microenvironment is a major challenge for in vitro cancer models.
Time or the temporal microenvironment is a parameter that is often overlooked in 3D cell culture.
Tumor microenvironment is a complex system composed of a largely altered extracellular matrix with different cell types that determine angiogenic responses and tumor progression.
The interplay between hematopoietic stem and progenitor cells (HSPC) and their local microenvironment is a key mechanism for the organization of hematopoiesis.
The introduction of bioactive molecules into three-dimensional porous scaffolds to mimic the in vivo microenvironment is a promising strategy for tissue engineering and stem cell research.
Our study provides strong evidence to directly demonstrate that targeting TLR2 to overcome tumor cell-induced immunosuppressive microenvironment is a novel therapeutic strategy against tumor metastasis.
The concept that the stromal microenvironment is a crucial regulator of tumor development was originally proposed by Paget many years ago in his "seed and soil" hypothesis [1].
The question of whether intact somatic cells committed to a specific differentiation fate, can be reprogrammed in vivo by exposing them to a different host microenvironment is a matter of controversy.
As illustrated above there is a strong support that the interaction between EOC and its surrounding microenvironment is a primordial step in the development and progression of metastatic EOC.
Hypoxia in the microenvironment is a characteristic of malignant tumors.
