The tumour microenvironment has an important role in cancer progression and in vitro assays have shown that matrix-derived peptides could be the important factors (Hornebeck et al, 2002).
It has long been recognised that the tumour microenvironment has an important role in the biological behaviour of cancer [ 5].
The tumour microenvironment has an important role in the natural evolution of cancer and its response to immunotherapy.
The cross talk between cancer cells and their microenvironment has an important influence on tissue homeostasis and progression of cancers [ 6].
Emerging evidence suggests that the inflammatory tumour microenvironment has an important role in modulating drug resistance (DeNardo et al, 2011; Shree et al, 2011); however, underlying mechanism has been still largely unknown.
Variations in TCR strength at different stages of differentiation as cells migrate through the Hh microenvironment could have important consequences on the outcome of repertoire development.
The tumour microenvironment, comprising multiple cellular and molecular factors, has important roles in the biological behaviour of cancer (Hanahan and Weinberg, 2011).
Our data indicates that the microenvironment supported by astrocytes in the normal ONH in AA has important differences that may impact susceptibility to glaucomatous optic neuropathy.
Thus, understanding these effector pathways in unique autoimmune microenvironments might have important implications in term of autoimmune disease pathogenesis as well as the development of rational therapies.
8 The bone microenvironment has become an important focus of basic and clinical research efforts.
