Sentence examples for microenvironment exerts a from inspiring English sources

Our results suggest that the immune microenvironment exerts a strong selection pressure in early-stage, untreated non-small-cell lung cancers that produces multiple routes to immune evasion, which are clinically relevant and forecast poor disease-free survival.

Whether or not loss of S100A10 in the tumour microenvironment exerts a functional role in follicular thyroid neoplasia is a subject of future investigations.

Moreover, the accumulation of myeloid-derived suppressor cells (MDSC) in the tumor microenvironment exerts a profound effect on tumor progression through their potent immunosuppressive activity on T cells.

Frossi, B., De Carli, M., Piemonte, M. & Pucillo, C. Oxidative microenvironment exerts an opposite regulatory effect on cytokine production by Th1 and Th2 cells.

The epigenetic model posits that the host microenvironment exerts an initial inhibitory constraint on tumor growth that is followed by acceleration of tumor progression through complex cell matrix interactions with the host stroma.

While competing for the same integrin receptors that are preferentially upregulated in the tumor microenvironment, VCN exerts a potent inhibitory effect on endothelial cell (EC) migration and tube formation in a dose-dependent manner, by forcing these cells to undergo significant actin cytoskeleton reorganization when exposed to this agent in vitro.

Given the dynamic and reciprocal relation between ECM and normal mammary epithelial cells, it is not surprising that the microenvironment also exerts a significant effect on tumour cell behaviour [ 8].

The cellular dimensionality and microenvironment exert an essential influence on cancer drug sensitivity [ 9, 10] or resistance [ 11, 12] of 3D cultures relative to 2D monolayers.

Further, trabectedin has profound activity on the tumor microenvironment, exerting effects on quiescent tumor-promoting monocytes and macrophages that is atypical of a DNA-directed alkylating agent [ 96].

This systemic toxicity of CD24 targeting by mAb in a syngeneic tumour model also did not allow the analysis of the changes in the tumour cytokine microenvironment exerted by the anti-CD24 mAb or the extent of ADCC or CDC contribution to the anti-tumour effects of anti-CD24 mAb in immunocompetent mice.

Noteworthy, we also show that CXCL8 and PGE2, two of the inflammatory factors that are significantly enhanced in PDAC plasma, are involved in the DC activation and we speculate that multiple inflammatory factors leak out from the tumor microenvironment and exert a systemic effect on the immune cells.