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Accumulation of adenosine into the tumour microenvironment does not only protect tumour cells from the immune response, but may also exert a trophic effect on the tumour itself by stimulating endothelial cell proliferation and angiogenesis [18], [19], [20].

But arrival at the secondary microenvironment does not guarantee proliferation as the cell may remain dormant or even die.

26 Against this hypothesis, our data show that the BM-altered microenvironment does not affect the therapy's efficacy.

The endoneurial microenvironment, unlike the cerebral microenvironment, does not require a moment-to-moment regulation of nutrients and oxygen.

In addition, the use of mouse models often presents ethical issues and, more importantly, the mouse mammary microenvironment does not faithfully recapitulate the human mammary microenvironment [ 11].

In fact, the absence of this lectin in both tumor cells and within the tumor microenvironment does not seem to interfere with the tumorigenic process as all galectin-3 KO mice injected with Tm1 cells developed tumors (Fig.  1C).

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However, the spread of this microenvironment did not deteriorate the patient's prognosis.

However, both immune and malignant cells in the tumor microenvironment do not express typical MHC molecules.

Moreover, the grade of infiltrating CD8 T cells within tumor microenvironment did not differ between calreticulin-strong and -weak groups.

Tellingly, although the cells within the tumor microenvironment do not undergo malignant transformation, dramatic changes in their gene expression profiles distinguish them from their normal counterparts [ 5, 6].

Together, these data suggest that cell proliferation, cell death, and fascin-deficient microenvironment do not contribute significantly to prolonged survival of FKPC mice.

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