Sentence examples for microenvironment affects the from inspiring English sources

We are also interested in understanding understand how the microenvironment affects the response to immunotherapy, including CAR-T cells.

However, it is not known whether the metabolic microenvironment affects the function of immune cells by modulating ER homeostasis, particularly in innate T-lineage iNKT cells.

Although they can serve as focal points for association of signaling molecules and downstream pathways that regulate tumorigenesis, little is known about how the tumor microenvironment affects the expression and activity of scaffold proteins.

The goal of the present work is to establish a basic in vitro 3D spheroid model of human mesothelioma and to investigate how the tumor microenvironment affects the penetration and killing activity of the immunotoxin SS1P targeting mesothelioma.

Although the microenvironment affects the pathogenesis of diseases, and in vitro evaluation is not perfect, this study suggests that iPS cells could be used to select between multiple available treatments, allowing physicians to advise each patient individually.

Here, we examined how the tumor microenvironment affects the penetration and killing activity of SS1P in a new three-dimensional (3D) spheroid model cultured in vitro using the human mesothelioma cell line (NCI-H226) and two primary cell lines isolated from the ascites of malignant mesothelioma patients.

Our data show that density, spatial placement, conjugation chemistry, and microenvironment affect the optical properties of the probes.

As a group, IMiDs broadly affect various molecular and cellular elements within the tumor microenvironment, affecting the concentration of various cytokines that support tumor cell growth.

These findings indicate that integrated cues from the microenvironment affect the cell reaction, for example, accelerating or impeding the cell migration.

The growth in vitro of leukemic cells, on the stromal MS5 cells in part mimics this BM microenvironment, affecting the sensitivity of leukemic cells to antineoplastic agents.

The mechanical properties of the microenvironment affect the morphology, adhesion, motility, and protein expression of many cell types, including myocytes, 2) mesenchymal stem cells, fibroblasts, endothelial cells, 7) neutrophils, 7) and smooth muscle cells.