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The objective of this pilot study was to determine whether differences in microcirculatory function and vasoreactivity could be measured in cardiac surgery using StO2 and VOT.
It is common for critically ill septic patients to have a disjunction between macro- and microcirculatory function, and this has also been recently demonstrated in patients following THS [9].
Basic physiology and recent research [8, 9] indicate that it is the delicate interplay of four key features determining cardiovascular failure and tissue hypoperfusion in septic shock: cardiac output, vascular resistance, microcirculatory function, and time.
Rheological properties in general are a major factor determining microcirculatory function and blood flow.
These include dysfunction of gingival fibroblasts, a decrease in microcirculatory function and immune system deficiency.
In particular, a worsening of microcirculatory function and nitric oxide bioavailability during storage has been described [ 26– 28].
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This study aimed to investigate the acute effects of the stable and active Ang-1 variant MAT.Ang-1 on the microcirculatory function (permeability, resistance and blood flow) in an experimental model of sepsis.
Hence, a growing body of evidence exists associating depressed microcirculatory function with morbidity and mortality in a wide array of clinical scenarios.
These autoregulatory mechanisms, and thus microcirculatory function, are severely disrupted during sepsis, and their dysfunction is a defining factor in the pathophysiology of sepsis [ 1].
Volume provision also restores microcirculatory barrier function and promotes microcirculatory oxygen transport [ 23, 50, 52].
As the intended physiological benefit underpinning RBC transfusion is to improve tissue oxygenation, several studies utilizing a wide range of assessment techniques have attempted to study the effects of transfusion on tissue oxygenation and microcirculatory function.
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microcirculatory failure and
microcirculatory vascularity and
microcirculatory flow and
microcirculatory oxygenation and
microcirculatory perfusion and
microcirculatory unit and
microcirculatory imaging and
microcirculatory vasodilation and
microcirculatory injury and
microcirculatory hypoperfusion and
microcirculatory density and
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