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Patients with an initial positive culture and at least one follow-up culture were considered microbiologically evaluable and were evaluated as "microbiological success" (eradication) or "microbiological failure" (persistence or superinfection) at discharge.
First, overall clinical success analysis was performed on the ITT and CE populations; second, microbiological success was analysed for the microbiologically evaluable population; third, AEs were analysed for the ITT population.
Microbiological success rate analysis was performed on microbiologically evaluable patients (all patients in the CE population who had a causative Gram-positive organism isolated at baseline); the pooling result showed that the microbiological success rate of daptomycin was similar to that of comparator drugs (six RCTs, 1173 patients, OR=1.05, 95% CI 0.61 to 1.79, p=0.86, I=42%; figure 3A).
If this was not successful, ITT analyses were conducted for all dichotomous outcomes (eg, clinical success, microbiological success, treatment-related AEs, all-cause mortality).
The microbiological success rates were evaluated in four trials.
Microbiological success rates were similar to the respective global successes.
Similar(12)
Microbiological outcomes were similar to clinical outcome, with 83.6% microbiologic success rate among ESBL producers.
The total microbiological treatment success of ertapenem group was numerically higher than piperacillin/tazobactam group in microbiologically evaluable population at TOC visit, while there was no significant difference (1699 patients, FEM, OR: 1.11, 95% CI: 0.84-1.47, Figure 3).
All the 6 relevant RCTs provided the microbiological treatment success.
In the subgroup analysis including with cIAIs and APIs, no difference was found regarding microbiological treatment success between ertapenem and piperacillin/tazobactam treatment arm (4 RCTs, 1107 patients, FEM, OR: 1.11, 95% CI: 0.76-1.61, Figure 3).
In the sensitivity analysis limited to double-blind RCTs, we got unchanged findings with the overall analysis regarding microbiological treatment success (5 RCTs, 1475 patients, FEM, OR: 1.17, 95% CI: 0.88-1.57).
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