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Microbiological screening was performed upon admission and twice weekly thereafter according to a standardised protocol.
Conventional markers of infection (C-reactive proteine, fibrinogen, white blood cell count and body temperature) as well as microbiological screening was performed simultaneously.
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In a French study performed in a medical ICU between 1993 and 1997, costs of an MRSA control policy (including contact isolation and microbiological screening) were calculated to be $655 to $705 per patient for an average length of stay of 20 days ($33 to $35 per day) [ 2].
Microbiological screening data was extracted from the medical microbiology database.
Toxicology (in vivo) and safety analysis (pyrogen testing, microbiological and bacterial DNA screening) was performed in accordance with the requirements of the CRC regulatory committee UK (Begent et al, 1993).
In case suspect samples (based on the in-house microbiological screening assay) were analysed, the indicative values derived from the screening assay were used to determine standard addition levels.
Combining organic chemistry with microbiological (or physiological) testing to achieve the selection of therapeutic leads among thousands of chemicals, screening was invented in Germany and became the norm for pharmaceutical research after 1945.
Before screening was introduced, cases were identified only if they had developed signs of infection or if mechanical ventilation had prompted a microbiological screening (it was current practice on the ward to perform microbiological screening of sputum in mechanically ventilated infants).
Rapid screening tests may further improve MRSA control, because traditional microbiological methods for MRSA screening are slow [ 12].
We do however recognize the limitations of this retrospective study which was only based on the collection of routine microbiological samples with no screening being carried out to detect asymptomatic carriage upon hospital admission.
Improvement of equipment design and cleaning procedures are desirable and continuous microbiological surveillance of endoscopes used in CRC screening is recommended.
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