Exact(1)
These lipophilic side chains predominantly differentiate the three echinocandins, resulting in variations in solubility, microbiological potency, and pharmacokinetic disposition [ 3- 5].
Similar(59)
Ciprofloxacin; microbiological standard, potency 85,5%, MW = 331.34 g/mol and moxifloxacin; microbiological standard, potency 91%, MW = 401.4 g/mol) were obtained from Bayer Healthcare AG (Leverkusen, Germany).
The aim of this work was to develop and validate a new microbiological assay to determine potency of linezolid in injectable solution.
It was studied against three bacterial strains, that is, Salmonella typhi, Pseudomonas aeruginosa, and E. coli, using cylinder plate method of microbiological assay (used for the potency determination of antibiotics) [ 30].
The API in each product was measured by a validated microbiological assay and compared by slope (potency) and intercept (concentration) analysis of linear regressions.
Despite their limitations, microbiological assays are widely employed to determine antibiotic potency of pharmaceutical dosage forms, since they provide a measure of biological activity.
The latter further improves safety as the decreased level of manipulation required lowers the risk of microbiological contamination, and in the case of CD34 + stem cells, allows preservation of multi-potency.
The similar pharmacokinetic profiles obtained in both independently conducted studies using two different methods, namely a microbiological assay and HPLC, provide support to the reliability of these data and further indicate that the antimicrobial potency of daptomycin used for the daptomycin no 1-study was equivalent to that used 10 years later for the daptomycin no 2-study [ 37].
Firrea carries similar potency.
Their microbiological age soon lags behind their biological age.
Marler plunged into microbiological research on E. coli.
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