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Microbiological eradication was defined as a negative culture, i.e. no pathogen isolated in tracheal aspiration.
In none of them, microbiological eradication was achieved (Table 2).
Microbiological eradication was demonstrated in only four of the eight patients.
In contrast to the clinical response, no microbiological eradication was noticed in any of the patients.
Microbiological eradication was concluded when there was no further bacterial growth of causative organism(s).
In all cases, except for patient 9 who was not treated, microbiological eradication was obtained.
Similar(48)
Low ratios of failing microbiological eradication were found by Montero et al. (eradication in only 7 of 13 treated patients for pneumonia).
Specifically, clinical cure and microbiological eradication were achieved in 32/37 866%) and 29/35 833%) patients, respectively, with initial optimal Cpeak/MIC, compared to 16/23 (70%) and 14/23 (61%), respectively, patients with insufficient initial Cpeak/MIC (P = 0.18 and P = 0.07).
As may be expected, the combined rates of microbiological eradication/presumed eradication were slightly higher than the clinical success rates.
The clinical cure rate and microbiological eradication percentage were higher when TGC was used at higher doses (57.5 versus 33.3; P = 0.05, and 57.1% versus 30.4%; P = 0.07, respectively).
In the VAP subpopulation (63 patients: 30 received SD and 33 HD), the clinical cure rate and microbiological eradication percentage were higher when TGC was used at higher doses (57.6% vs. 33.3%; P = 0.08 and 57.1% vs. 30.4%; P = 0.1).
More suggestions(15)
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microbiological confirmation was
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