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To evaluate the clinical and microbiological efficacy and safety of three doses of 3 g fosfomycin tromethamine administered orally to treat lower urinary tract infections.
The patients with a cured or markedly improved clinical outcome were followed up 7 days after the treatment for microbiological, efficacy and safety assessments.
We prospectively recorded the clinical and microbiological efficacy, and safety profile of colistin (polymyxin E) in the treatment of MDR Gram-negative bacterial infections in an ICU, during a period of 18 months.
In order to obtain a deeper understanding of its therapeutic effect in domestic patients, we evaluated the clinical and microbiological efficacy and safety in patients with lower UTI from 12 research centres in China.
This is a 'real practice' multicentre, open-label, phase III randomised controlled trial, designed to compare the clinical and microbiological efficacy, and safety of intravenous fosfomycin (4 g/6 h) and meropenem (1 g/8 h) as targeted therapy for this infection; a change to oral therapy is permitted after 5 days in both arms, in accordance with predetermined options.
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Clinical efficacy, microbiological efficacy, overall efficacy and safety were evaluated on day 15.
This fosfomycin tromethamine dosing regimen showed clinical and microbiological efficacy with some AEs and good tolerability in patients with acute uncomplicated cystitis, recurrent lower urinary tract infection and complicated lower urinary tract infection.
Given that the clinical and microbiological efficacy are similar for the 200, 300, and 400 mg doses, the lowest effective dose of 200 mg once daily for 6 days was selected for Phase III studies in acute bacterial skin and skin-structure infections, providing a safe dosing regimen with low potential of developing myelosuppression.
However, bacterial coverage rate might be accurate for comparing antibiotic regimen such as nitrofurantoin and fosfomycin which demonstrated similar clinical and microbiological efficacy on susceptible strains in previous studies [ 23- 25].
The aim of this study was to evaluate the comparative microbiological efficacy of hand rubbing and handwashing in healthcare workers from different wards, with particular emphasis on transient flora, and to assess predisposing factors for hand contamination after patient care in everyday practice.
Overall efficacy was assessed on patients for whom clinical and microbiological efficacy data were available by day 15.
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microbiological study and
microbiological detection and
microbiological aetiology and
microbiological expertise and
microbiological diagnosis and
microbiological examination and
microbiological evaluation and
microbiological failure and
microbiological culture and
microbiological laboratory and
microbiological analysis and
microbiological sampling and
microbiological culturing and
microbiological management and
microbiological information and
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