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Simulation realized using the estimated surface concentration and a simplified equation for the growth inhibition kinetics of Saccharomyces cerevisiae were compared to microbiological efficacy assessment.
The aim of this study was to evaluate the comparative microbiological efficacy of hand rubbing and handwashing in healthcare workers from different wards, with particular emphasis on transient flora, and to assess predisposing factors for hand contamination after patient care in everyday practice.
Clinical efficacy, microbiological efficacy, overall efficacy and safety were evaluated on day 15.
The microbiological efficacy for each patient with a positive urine culture was evaluated from day 1.
Microbiological test results showing 'eradication', 'replacement' or 'reinfection' were considered 'effective', and were used to calculate the microbiological efficacy rate.
Overall efficacy was assessed on patients for whom clinical and microbiological efficacy data were available by day 15.
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The main end points of this study were clinical efficacy, microbiological response and the development of AKI.
17 In line with this, the current study showed clinical, microbiological and overall efficacy rates of 62.69%, 83.87% and 64.52%, respectively, in the treatment of complicated lower UTI.
As we aimed to evaluate the clinical, microbiological and overall efficacy of fosfomycin tromethamine, the study design did not include a control group.
In line with this, we obtained clinical, microbiological and overall efficacy rates of 94.71%, 97.65% and 95.29%, respectively, for the treatment of AUC using fosfomycin tromethamine; and 77.22%, 94.44% and 77.78%, respectively, for recurrent lower UTI.
This is due to the fact that our primary objective was to evaluate the clinical, microbiological and overall efficacy of fosfomycin tromethamine, an antibiotic which is widely used abroad, but less in China, for the treatment of UTI.
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