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Microbiological documentation of infection was possible in38 patients (62%): 16 (44%) gram negative, 7 (18%) gram positive, 2 (5%) fungus, 2 (5%) other and 11(29%) polimicrobial.
P227 Microbiological documentation of pneumonia in the ICU by per-bronchoscopic bronchial aspiration (PBA) is very similar to that obtained by bronchoalveolar lavage (BAL).
Microbiological documentation of sepsis was achieved in 85 patients (74.6%).
Neither microbiological documentation of sepsis nor the presence of bacteraemia was related to a worse outcome.
Moreover, BG detection preceded microbiological documentation of fungemia by 1 to 3 days.
For other foci, distinct radiological or microbiological documentation of the foci and recovery during the antimicrobial treatment were required.
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Even so, the rate of microbiological documentation for patients accrued in Europe and Australia is running at 60%, and the rate for the trial overall will probably reach 50%.
In ICU patients with CAP, 3GCs given on an empirical basis are changed, according to microbiological documentation, for another beta-lactam in 82% of cases especially to A/C in the absence of resistance risk factor.
All VAP have microbiological documentation (for definitions, see Additional file 1).
The microbiological documentation rate of all IPA patients via either pus or correlated blood cultures was 83.0% (73/88), including 59.3% (51/86) with positive blood culture, and 75.7% (53/70) with positive pus culture.
Another major limitation was the large proportion of patients lacking microbiological documentation in the absence of guidance on the duration of empiric antibiotic therapy.
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