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The strengths of the study are (1) the relatively high sample size, (2) the complete follow-up for the endpoints due to good clinical practice-based clinical monitoring and follow-up based on the Danish hospital registers and (3) the completeness of data on a wide variety of clinical, biochemical, radiological and microbiological data in these patients.
There was not any microbiological data in 986 (69.83%) patients in this group.
Empiric antibiotics were not streamlined despite favourable microbiological data in the remaining 38 patients (Group III).
Antimicrobial prescriptions were made empirically in 2275 (78.4 %) of patients and according to microbiological data in 334 (11.5%).
Use of microbiological data in conjunction with the Clinical Pulmonary Infection Score (CPIS) improves VAP diagnostic specificity [ 1].
It may be worthwhile to examine genetic variants alongside clinical, serological, and microbiological data in order to more accurately predict disease behavior.
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Interventions consisted of insertion in medical records of written treatment recommendations by an ID physician based on International [ 11- 13] and Spanish [ 14- 16] treatment guidelines adapted to local data on antimicrobial susceptibility after examination of patients, clinical records and microbiological data (if any) for each patient in the intervention group.
The patients who were diagnosed and followed by primary care centers have microbiological data recorded in a microbiology registry compiled with data from specialty clinics, but no electronic medical record.
Supportive microbiological data were missing in 5 cases; diagnosis in these cases was based on the investigator's judgment.
This is the reason why a continuous survey of microbiological data is mandatory in order to identify most common pathogens in each single centre in terms of annual incidence and prevalence related to primary clinical outcome.
Microbiological data are outlined in Table 1.
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