Sentence examples for microbicides in the from inspiring English sources

This study is designed to test the hypothesis that tenofovir (TNF) or tenofovir disoproxil fumarate (TDF) loaded nanoparticles (NPs) prepared with a blend of poly(lactic-co-glycolic acid) (PLGA) and methacrylic acid copolymer (Eudragit® S-100, or S-100) are noncytotoxic and exhibit significant pH-responsive release of anti-HIV microbicides in the presence of human semen fluid simulant (SFS).

Therefore, testing of raltegravir and maraviroc as topical microbicides in the RAG-hu mouse model of sexual HIV-1 transmission is likely to provide critical pre-clinical data in this context as well.

We examined the role of specific endogenous microbicides in the reduction of HIV infection of target cells by CVL from HIV and HIV women, finding that the levels of HBD2 and MIP3α correlated significantly with inhibition of infection.

That endogenous microbicides in the female reproductive tract secretions might limit or prevent HIV transmission is suggested by the relatively low risk of HIV transmission per heterosexual coitus, from 1∶122 to 1∶1000 [4], [4].

The reasons for discussing microbicides in the future when they are known to prevent HIV acquisition and are widely available, are likely to be different to the reasons for discussing microbicides in the context of a placebo-controlled clinical trial.

They were administered verbally by research assistants who were trained to explain microbicides in the context of heterosexual contact, how it will be applied and the anticipated benefit of protecting against HIV infection.

Postintervention, 40% endorsed having heard about the use of HIV medications to prevent HIV infection; 72% had heard that male circumcision can decrease the risk of acquiring HIV infection in men; and 73% endorsed knowledge of the potential role of microbicides in decreasing the risk of acquiring HIV.

The role of nanotechnology in the antiviral arena and the unique issues facing the generation of intellectual property relating to nano-microbicides in the ongoing global 'tug-of-war' of 'patients versus patents' are also explicated.

This finding provides optimism regarding the acceptability of a lubricant-based microbicide in the broader community if a microbicide gel is found to be effective against HIV.

The lower panel in Fig. 5 shows two methods for testing the protective efficacy of a candidate microbicide in the mouse HSV model.

Microbicide in the form of 1% tenofovir vaginal gel when tested in a Phase IIb trial (CAPRISA 004) in a coitally dependent manner revealed that tenofovir gel users were 39% less likely to become HIV-infected compared to placebo control.