Sentence examples for microbicides have shown from inspiring English sources

To date, microbicides have shown potential in blocking HIV in tissue culture, but have failed to protect in clinical trials.

On the other hand, recent trials on anti-HIV-1 vaccines and microbicides have shown that some of current vaccine and microbicide strategies not only did not prevent but actually increased HIV-1 infection and transmission risks [ 20- 23].

Recent trials with microbicides and vaccines have shown some ability to prevent HIV-1 transmission but the efficacy has been low.

A study in sub-Saharan Africa of a method to help prevent heterosexual transmission of HIV to women has been stopped midcourse as early data have shown that the microbicide, a vaginal gel laced with an antiviral drug, failed to reduce the rate of new infections.

To define the mechanism(s) through which CVL from HIV and women protect target cells from HIV infection, we analyzed CVL specimens for key endogenous microbicide candidates which we and others have shown in cell culture to have antiviral activity [9] [12].

Human monoclonal antibodies (mAbs) based on IgG and IgA have shown promise as topical microbicide candidates to protect women from HIV infection.

Several of these studies have shown male partner interest in microbicide research [ 15- 18].

Vaginal and rectal exposure models in non-human primates have shown the feasibility of tenofovir as a topical microbicide and oral PrEP by protecting the majority of the animals challenged with SHIV [17], [18], [54].

We and others have shown similar protection using this model with other microbicide candidates [ 13, 42- 44].

Trials have shown that certain HIV medications, when taken by HIV-negative individuals orally or applied as a microbicide gel, can help protect them from becoming infected, an approach known as pre-exposure prophylaxis, or PrEP.

Evidence from MDP 301 and other microbicide trials has shown that many women describe microbicides as being cleansing and hygienic [ 58– 61].