Sentence examples for microbicides based on from inspiring English sources

This article forms part of a special supplement on presentations covering HIV transmission and microbicides, based on the symposium "Trends in Microbicide Formulations", held on 25 and 26 January 2010, Arlington, VA.

Unfortunately, microbicides based on N-9 enhanced the susceptibility of sexual transmission of HIV-1.

Clinical trials of microbicides based on N-9 and C31G failed to inhibit sexual transmission of HIV.

Microbicides based on nonoxynol-9 (N9) and other detergents disrupt sperm, HSV and HIV membranes, and these agents are effective contraceptives.

Milligan et al. also reported that two non-detergent candidate microbicides based on sulfated and sulfonated polymers, T-PSS and PRO 2000, did not cause significant increases in vaginal leukocytes even after repeated doses.

In spite of good anti-HIV-1 activity in various in vitro assays and challenge experiments in macaques, clinical trials of microbicides based on surfactants and polyanions failed to inhibit sexual transmission of HIV-1.

For example, blocking receptor interaction could be exploited for the development of novel types of vaginal microbicide based on mini-CD4 molecules and on broadly neutralizing mini-antibodies, which also have potential for blocking mucosal infection [ 11] of women.

This has been reported in studies evaluating hypothetical willingness to use microbicides [ 11– 15], microbicide acceptability based on the use of surrogate products [ 16– 20], as well as trials evaluating the acceptability of candidate microbicides [ 5, 21�� 23].

111, 112 Several microbicide clinical trials based on the successful in vitro anti-HIV efficacy of the microbicide candidates, however, have failed to demonstrate in vivo efficacy, presenting (except the CAPRISA 004 trial) the discrepancies between the in vitro and in vivo data.

That would, indeed, be a "fit and forget" method that would protect against infection from demands for instant sex by drunken husbands although Zeda Rosenberg, the head of the International Partnership for Microbicides observes that some men find the gels enhance their experience and encourage their use.Dr Rosenberg's ultimate microbicide would be based on the drugs used in HAART.

Notably, there is increasing interest in the identification of microbicide approaches not based on drugs used as first line therapies against HIV-1 and/or that exhibit cross-resistance, to limit the emergence of drug resistant viruses.