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Dictionary
microbicides
noun
Plural of microbicide
Exact(60)
This would have suggested that although PRO 2000 was not a complete answer, it might be a useful part of the armoury.The dashing of that hope is a real blow, but there are other approaches to vaginal microbicides.
Abdool Karim is part of an international trial of the product managed by the International Partnership on Microbicides and the Microbicide Trials Network.
Working with sex workers, Abdool Karim had the idea of a HIV barrier gel that women could use to prevent themselves from HIV. She'd heard about microbicides – compounds that can be put inside the vagina or rectum to protect against sexually transmitted infections.
But three trials of microbicides have now failed, and so have two herpes-suppression trials and one trial of diaphragms.
One of the goals of the new initiative is to prove to "big pharma" that microbicides could generate a big enough demand, and thus be worthy of the $500m investment that the foundation reckons it would need to bring a product to market.
Microbicides and other interventions could have been tested when only hundreds of thousands were infected, rather than tens of millions.
But Dr Rosenberg believes that at least some of the substances being considered as microbicides could be packaged into slow-release rings that a woman could wear in her vagina for a month or more.
An ounce of prevention Reprints Related items AIDS: The end of the beginning?Jul 15th 2004 AIDS microbicides: An ounce of preventionJul 15th 2004The question of how far the virus would spread beyond high-risk individuals is more moot.
Attempts to protect women, by developing vaginal microbicides that destroy HIV in infected semen, have been less successful.
Several techniques that they could use without male involvement are now undergoing thorough clinical trials.The first is vaginal microbicides.
The first is the idea of pre-exposure prophylaxis in other words, giving ARVs to uninfected people to clobber any new infection before it can get going.The second is to use ARVs as microbicides.
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