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But, perhaps because the one per cent of the microbial world that could be cultivated was so immense, few microbiologists gave it serious thought.
Because of its ability to reveal the previously hidden diversity of microscopic life, metagenomics offers a powerful lens for viewing the microbial world that has the potential to revolutionize understanding of the entire living world.
SCG generates a whole new way for exploiting bacterial diversity since, to date, biotechnological applications rely almost exclusively on the part of the microbial world that can be cultured, that is, less than 1% of the microbial diversity.
People frightened by a microbial world that harbors superbugs they believe are out to get them may be adopting an approach that actually fosters rather than suppresses serious infections.
"We humans are embedded in a microbial world that we barely acknowledge, and this study is one that is beginning to shed light on what kinds of organisms are out there in the environment," says microbiologist Norman Pace of the University of Colorado at Boulder.
Nitrogen-fixing organisms are found among denizens of the microbial world that occupy a great variety of ecological niches encompassing environments that differ in macro- and micronutrient composition, in trace metal availability, in pH, salinity, oxygen concentration, temperature (the current upper bound for N2 fixation is 92°C), and so on.
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This new method of "molecular ecology," Dr. Sogin said, "has revealed many different microbial worlds that no one suspected might exist".
"People have trouble understanding that we're embedded in an invisible microbial world" and that we are colonized by those microbes, says Olsiewski, whose program has given academic researchers more than $40 million in grants.
More fundamentally, however, the consideration of stabilisation processes in the microbial world indicates that the entities scientists work with are only relatively stable, their stability being dependent on the processes that sustain the functional integration of their parts.
Alternatively, however, such entities could be quite recent evolutionary innovations in the microbial world, an idea that seems at least plausible, since the evolution of single entities able to fulfil multiple distinct roles can be advantageous in terms of cellular economy.
"The adaptive potential of the microbial world is such that for each new antibiotic that is introduced, several escape mechanisms are soon devised".
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