Sentence examples for microbial translocation in from inspiring English sources

Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals.

The precise mechanisms, extent and effects of microbial translocation in HIV are only starting to be worked out[25], [28], [29], [30], [31].

Microbial translocation in HIV-infected patients is associated with increased LBP levels and decreased IgM antibodies to the LPS core oligosaccharide (EndoCAb) [3].

Brenchley et al. found that lipopolysaccharide (LPS) and soluble CD14 (sCD14), thought to be correlative markers of microbial translocation, in plasma were associated with CD8 T cell activation in chronic HIV-1 infection [12].

A possible explanation of the less efficient control over microbial translocation in this patients' cohort might be consistent with the dramatic structural damage of the intestinal barrier described in untreated advanced HIV/SIV infection [9], [17], with ever-increasing content of microbial by-products infiltrating intestinal lamina propria and gaining the circulation.

Through the joint quantification of gut-derived bacterial macromolecules and genotypes, we hereby assessed the quality of microbial translocation in peripheral blood of HIV-infected patients starting HAART with severe immune depression and lacking CD4+ recovery on therapy, and have made the following observations.

In this study, we investigated the association between markers of microbial translocation, alterations in circulating monocytes, and neurocognitive impairment (NCI) in a cohort of AIDS patients with a high frequency of IVDU and HCV co-infections and relatively high plasma VL.

Finally, in an unpublished work, we demonstrated that alcohol-induced mucosal alterations (and microbial translocation) resulted in increased levels of systemic immune activation and inflammation in chronically infected AGMs.

We hypothesized that the high levels of systemic inflammation observed in undernourished adults with advanced HIV in sub-Saharan Africa are due in part to excessive microbial translocation, and reductions in microbial translocation following treatment initiation accompany a normalization of this inflammatory response.

The hypothesis recently proposed by Brenchley and colleagues on microbial translocation fits well in this view, in that lipopolisaccaride (LPS) and other microbial components, systemically mobilized from the gut, may function as chronic stimuli resulting in phenotypic T cell activation [22].

Microbial translocation also occurs in inflammatory bowel disease (IBD).