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Among several hypercellulolytic fungal strains, filamentous fungi such as Trichoderma and Aspergillus sps are considered as the major microbial sources for production of cellulose-degrading enzymes [7,8].
Among several hyper-cellulase producing fungal strains, filamentous fungi, Trichoderma sp. and Aspergillus sp. are considered as the major microbial sources for production of cellulase enzymes (Gusakov 2011).
This has paved way for the discovery of newer microbial sources for the production of fibrinolytic and/or thrombolytic agents with increased fibrin specificity and longer half-lives (Peng et al. 2005).
Microbial sources for alpha-galactosidase are being explored because of ease of cultivation and fermentation conditions.
Several techniques including direct fermentation, simultaneous saccharification, simultaneous non-thermal saccharification, ultrasound assisted treatment and solid-state fermentation have been studied previously using different starchy materials and microbial sources for the production of bioethanol [ 20, 21, 51- 56].
Considering the vast amount of possible microbial sources for sulfatases, guidelines facilitating the search for novel sulfatase activities are desirable, which can be delineated from successful case stories in the literature.
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Acetobacter aceti MTCC 2623 was studied as an alternative microbial source for bacterial cellulose (BC) production.
These strains may be utilized as the microbial source for the degradative gene(s), and these genes can be transferred to non-degradative strains by recombinant DNA technology.
Also, the cellulase enzymes produced from A. terreus were highly active at low pH conditions and thermotolerant; thus it is a potential microbial source for hyperproduction of a broad range of cellulases for cellulose breakdown, especially towards enzymatic saccharification processes and bioethanol production.
Monascus is an ascomycete fungi widely utilized as a microbial source for production of natural pigments, including three major groups of Monascus pigments (red ones, monascorubramine and rubropunctamine; yellow ones, monascin and ankaflavin; and orange ones, rubropunctatin and monascorubrin) (Feng et al. 2012).
Our work identified a potential microbial source for neurodegeneration represented in the S. venezuelae metabolite and implies that other bacteria may also produce neurodegeneration-inducing secondary metabolites.
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