The dominant link between microbial life and geomorphology appears to take on different forms depending on the timescale under consideration, with a stabilising microbial role apparent over short timescales being replaced by a denudational role over longer timescales.
However, its significant gene-gene association with NOD2 and the lipopolysaccharide-signalling role of cell surface toll-like receptors [31], [32], provides strong evidence of a microbial role in CD genetically susceptible individuals.
Distinguishing between a bacterial association with lumbar disc herniation and contamination of the surgical wound by the normal skin microbiota is critical in defining a microbial role [ 14].
Finally, transcripts containing xanthine uracil permease domains and phosphoribosyltransferase domains were found, which participate in the purine salvage pathway and signify a potential microbial role for the recycling of purine nucleotides.
Various observations support a microbial role in NEC, including the high incidence of pneumatosis intestinalis (gas in the bowel wall) in affected infants and resolution of symptoms in a majority of patients after antibiotic therapy and bowel rest (Grave et al., 2007; Morowitz et al., 2010; Carlisle and Morowitz, 2013).
A similar approach has been followed to elucidate the potential direct anti-microbial role of hydrogen peroxide.
Hence, these observations suggest a microbial regulatory role of CRISPR, perhaps using a system based on interference [7], [13].
The annotated proteins were further assigned to functional groups according to the Comprehensive Microbial Resource role category [ 20].
But I would call for one additional effort: in the midst of all the thousands of microbial genomes, the role of one additional genome - the human genome - should also be fully evaluated.
Commensal bacteria comprise a large part of the microbial world, playing important roles in human development, health and disease.
