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However, we are facing increasing microbial resistance to antibiotic treatment and particularly worrisome is the emergence of resistant bacterial strains towards β-lactam antibiotics that can rapidly disseminate worldwide.
Its chapters, (illustrated with both medical facts and vignettes) deal in turn with insect-borne infections, diseases arising from foods, microbial resistance to drugs, influenza, various chronic ailments and bioterrorism.
It is in this context, combined with new realities of the 21st century – including recent failures of monetary and financial regulatory policy, the rise of China, and such unattended global problems as microbial resistance to drugs and climate change – that it is time for the US to reconsider its role as a donor and supporter of international development.
Development of microbial resistance to antibiotics is a major challenge in the medical field.
The emergence of microbial resistance to routinely used antibiotics has led to a demand for more effective antibiotics [12].
Often, the inefficiency of an antimicrobial treatment is due to microbial resistance to conventional antibiotics [2 5].
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It has been shown that anti-microbial resistance to one drug does not always correlate to the consumption of the same drug or closely related drugs [ 28].
Microbial resistance, especially resistance to cephalosporins, is an ever increasing public health problem worldwide among pathogenic Enterobacteriaceae, namely, Escherichia coli and Klebsiella pneumoniae [ 1].
Efflux mechanisms have been recognized as important components of microbial resistance of MRSA to various classes of antibiotics.
Their utility is threatened by the emergence of microbial resistance, mainly due to compound efflux (Thaker et al. 2010), covalent modification of the ribosome (Goossens 2009), or alteration of the antibiotic (Zhanel et al. 2012).
Novel synthetically-derived macrolides that preserve anti-inflammatory functions as well as overcome the risk of microbial resistance are needed to be investigated for the long-term treatment of chronic inflammatory respiratory diseases.
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