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Solid-state fermentation has emerged as a potential technology for the production of microbial products such as feed, fuel, food, industrial chemicals and pharmaceutical products.
Studies dating back from the 1970s showed that microbial products, such as LPS (lipopolysaccharide), negatively regulate respiration of macrophages by inhibiting complexes in oxidative phosphorylation20,21.
M1 macrophages are induced by interferon-γ and microbial products such as lipopolysaccharide [9].
Typical ligands for the TLRs are microbial products such as bacterial unmethylated deoxycytidyl-deoxyguanosine (CpG) DNA, and lipopolysaccarides or viral RNA or nucleic acids.
C5a has been shown to enhance TLR-mediated pro-inflammatory responses to microbial products such as LPS, contributing to sepsis syndromes [22], [25], [44], [45].
The Toll-like receptors (TLRs) are an important group of PRRs that respond to a range of microbial products such as lipopeptides and non-self nucleic acids [2].
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Previous studies indicated that production of microbial extracellular products such as enzymes and organic acids can increase the mineralization of nutrients (Chien 1979; Jansson et al. 1988).
Despite the efficiency of these techniques, identification and quantification of microbial degradation products such as 5α-androstanedione and 5β-androstanedione is still the preferred approach advocated by WADA in TD2014EAAS.
However, during the processing of hydrolysate for subsequent microbial fermentation, degradation products such as acetate, 5-hydroxymethylfurfural (HMF), furfural will be formed to various degree known to inhibit the microbial growth and product yields at higher concentration (Bellido et al. 2011; Nigam 2001a; Palmqvist and Hahn-Hägerdal 2000).
For materials technology, it can be transformed by chemical reactions or microbial fermentation into products such as propene, 1,3-propanediol, succinic acid, citric acid, oxalic acid, poly-3-hydroxybutyrate (PHB), and others [33],[33].
Other investigators observed synergistic interactions between MV and intravenously or intra-pulmonary microbial cell wall products such as lipopolysaccharide (LPS) [ 13, 14].
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