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Metabolic engineering and synthetic biology have enabled the use of microbial production platforms for the renewable production of many high-value natural products.
Thus, novel microbial production platforms are available that no longer compete with nutritional feedstocks.
Metabolic engineering via microbial production platforms has been advanced as an eco-friendly alternative approach for production of value-added nutraceuticals from simple carbon sources.
We argue that metabolic engineering for producing the secondary metabolites in plants may have distinct advantages over microbial production platforms, and thus propose new approaches of plant metabolic engineering, which are inspired by an ancient Chinese irrigation system.
Filamentous fungi such as Aspergillus niger are well known for their exceptionally high capacity for secretion of proteins, organic acids, and secondary metabolites and they are therefore used in biotechnology as versatile microbial production platforms.
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To improve compound supply for further investigation of MXN, COR and novel derivatives of these antibacterial agents, establishment of an efficient and versatile microbial production platform for myxobacterial α-pyrone antibiotics is highly desirable.
We have demonstrated that the new pathways are plausible alternatives for the construction of next-generation microbial propane production platforms.
The bacterial strain M5al is a model strain for studying the molecular genetics of N2-fixation and molecular engineering of microbial production of platform chemicals 1,3-propanediol and 2,3-butanediol.
This chapter addresses key developments in the microbial production of C3 platform chemicals, like propionic acid, 1,3-propanediol, and 3-hydroxypropionic acid, from various feedstocks.
We further discuss opportunities posed by emerging production platforms, namely microbial, plant and synthetic systems.
It indicates a promise of the developed technology platform for microbial production of n-butanol from the glucose glycerol mixture.
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