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The growth characteristics and underlying metabolism of microbial production hosts are critical to the productivity of metabolically engineered pathways.
Microbial production hosts are promising candidates for development and production of pharmaceutical proteins.
Recently, the introduction of PPRs in microbial production hosts has successfully led to light-driven biotechnological conversions.
Successful crude glycerol utilization requires robust microbial production hosts that tolerate and preferably, can utilize such impurities.
In this review, we discuss relevant features of natural PPRs, evaluate reported biotechnological applications of microbial production hosts equipped with PPRs, and provide an outlook on future developments.
However, bio-production of fatty acids from plants and other microbial production hosts relies heavily on manipulating tightly regulated fatty acid biosynthetic pathways.
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Saccharomyces cerevisiae, a eukaryotic model organism, is considered the ideal host for microbial production of plant secondary metabolites such as polyketides and alkaloids.
Despite the reported microbial production of alkanes, the toxicity of alkanes to microbial hosts could pose a bottleneck for high productivity.
The abundance of genetic information available for Escherichia coli and specifically, fatty acid metabolism in E. coli, supports this bacterium as a promising host for engineering a biocatalyst for the microbial production of fatty acids.
This work represents the first-ever microbial production of pentane and demonstrates that short chain n-alkane synthesis is conceivable in model cellular hosts.
Microbial synthesis of value-added compounds often depends upon the creation or introduction of heterologous metabolic pathways into production hosts.
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