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Bacterial survival in ETT biofilm can promote VAP microbial persistence and consequently affect patient prognosis.
Biofilm stands as a pathogenic mechanism for microbial persistence, and impaired response to treatment in VAP.
Clarification of whether E. coli-laden macrophages are attempting to ameliorate inflammation or whether they contribute to microbial persistence and disease pathogenesis will also be important.
In this situation, microbial persistence and impaired response to treatment (treatment failure and relapse) were more frequent (100% vs 29%, P = 0.021; 57% vs 14%, P = 0.133).
Microbial persistence and impaired response to treatment (treatment failure and relapse) were more frequent when multidrug-resistant microorganisms were present in ETT biofilm.
However, no attempt has been performed in order to assess the relationship among biofilm, microbial persistence and outcome of the VAP episode.
Similar(53)
The bacteria most frequently implicated in microbial persistence were A. baumannii and P. aeruginosa (seven of the nine cases).
Enterococcus faecalis Aggregation Substance (Asc10) protein enhances the severity of experimental endocarditis, where it has been implicated in formation of large vegetations and in microbial persistence during infection.
The investigators studied the high mortality figures in Pseudomonas VAP and evaluated causes of microbial persistence in the alveolar space despite adequate antimicrobial therapy.
This, coupled with the documentation of microbial persistence despite such short term antibiotic therapies, makes the case for longer and better treatments.
Microbial persistence was detected in 9 (64%) patients with VAP.
More suggestions(15)
microbial aetiology and
microbial disease and
microbial diversity and
microbial identification and
microbial zoo and
microbial population and
microbial growth and
microbial contamination and
microbial load and
microbial composition and
microbial staining and
microbial metabolism and
microbial adhesion and
microbial sepsis and
microbial spoilage and
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