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TLR agonists are generally microbial molecules that stimulate TLR receptors to initiate specific immunoactivity.
PAMPs include a growing list of essential conserved microbial molecules that are not normally present in the plants such as lipopolysaccharides (LPS), flagellin, glycoproteins, chitin etc [19].
The general strategy of innate immune detection is one in which a limited number of receptors are dedicated to the recognition of microbial molecules that are conserved across broad taxa, and, for the most part, the receptors must be indifferent to molecules of host origin (the basis of innate immune discrimination between self and non-self) [ 34].
NOD9 is a member of the NLR family known to recognize microbial molecules that activate inflammatory caspases, causing cleavage and activation of inflammatory cytokines [ 48].
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Vitex's technique works by mixing them with a solution containing an anti-microbial molecule that belongs to a family of chemicals known as ethyleneimines.
NOD-like receptors are involved in the recognition of host-derived and microbial danger-associated molecules that lead to the assembly of high-molecular-mass complexes called inflammasomes and the subsequent generation- of active caspase 1, a requisite for the production of the inflammatory cytokine IL-1β [ 7].
The natural microbial ligand molecule that activates the AI-3 receptor complex has not been clearly defined but is probably similar to catecholamines.
Besides TLRs, there are also other pattern recognition receptors (PRRs) present in PBMCs that detect a variety of microbial molecules, including NLRs, that contain a NOD- and ligand-recognizing leucine-rich repeat [ 35].
Anti-microbial peptides are effector molecules that are produced in the fat body, hemocytes, and epithelial tissues.
NOD-like receptors (NLRs) are a group of cytoplasmic molecules that recognize microbial invasion or 'danger signals'.
This system is activated by the general features of microbial cells; for example, the molecules that make up the walls surrounding most bacteria.
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