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Swann, J. R. et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments.
EHEC O157∶H7 disease pathogenesis also is related to microbial modulation of eukaryotic signal transduction cascades.
This suggests that the altered innate immune system may play a direct role in the method of microbial modulation of diabetes in the metabolic syndrome.
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Here, we review recent metagenomic and metabonomic approaches that have enabled advances in understanding gut microbiome activity in relation to human health, and gut microbial modulation for the treatment of disease.
The ability to identify bacterial groups that are spatially disturbed in UC may influence the future use of microbial modulation in the treatment of this condition.
However, the long-term functional or metabolic consequences for the host of microbial modulation are poorly understood.
The finding that environmental influences can overcome the impact of host genetics on gut microbial composition suggests that microbial modulation strategies (such as probiotics) are feasible, even in the face of strong genetic influences on the intestinal microbiota.
However, gut microbial modulation is not always initiated by medical intervention, and small bowel transplants used in cases of intestinal failure permit an opportunity for long-term study of the microbial ecology of the human small bowel.
Together, we identify microbial modulators of the NLRP6 inflammasome and highlight mechanisms by which microbiome-host interactions cooperatively drive microbial community stability through metabolite-mediated innate immune modulation.
29 The aim of our exploratory study was to evaluate the impact of ITF prebiotics on the gut microbial ecosystem in obese women to highlight the contribution of gut microbial changes in the modulation of host metabolism on nutritional intervention.
Environment specific selective pressures have always been the apex driving force in the modulation of microbial genomes' stability [ 105].
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