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Genomes of the major microbial model organisms have been sequenced, some multiple times; projects to sequence new genomes will select from a pool of increasingly obscure organisms.
A further metabolic division among microbial model organisms for longevity is prokaryotes and eukaryotes.
Insight into the mechanisms behind CR has been greatly facilitated by studying a variety of microbial model organisms.
The pathways, proteins, and metabolism involved in the initiation or regulation of the CR-mediated longevity in assorted microbial model organisms will be addressed in this review.
Although microbial model organisms can assist in elucidating highly conserved mechanisms, mediating the metabolic response to CR in mammalian cells, microbes also play a direct role in mammalian metabolism.
But microbes can help us understand CR both within and without: not only can microbial model organisms enlighten us on how our cells age, but intestinal microbes can control our exposure to nutrients and enforce CR exogenously.
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We utilize genome engineering, DNA synthesis, and next-generation sequencing methods to better understand genome evolution and population dynamics of a variety of model organisms and microbial communities under different environments.
Numerous interdependent factors have been shown to affect protein evolution in simple model organisms such as yeasts or microbial systems (reviewed by Pál et al. 2006).
However, insights from microbial ethylene production via genome engineering efforts in model organisms such as Escherichia coli will guide engineering of an array of microbes including cyanobacteria for the direct production of ethylene from CO2 and sunlight.
Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms.
The biochemistry and enzymology of methanogenesis is well known for model organisms, but the functioning of biogas-producing microbial communities on the whole is insufficiently explored.
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