Exact(2)
However, a better understanding of which bacteria or bacterial populations are relevant to UC and IBS is an important prerequisite if microbial interventions are to be used in preventing or managing these conditions.
There was speculation that the gut microbiota should be considered a separate organ, and whether analysis of an individual's microbiota could be useful in identifying their disease risk and/or therapy; however, more research is needed into specific diseases, different population groups and microbial interventions including probiotics.
Similar(58)
This seems even more feasible as microbial intervention and microbial data are more clinically actionable than human genetic data.
Our findings suggest that microbial intervention therapy will have the potential to help control blood lipid levels and prevent disease.
Similarly to the effects on the GI microbial communities, antibiotic intervention did not significantly affect the serum metabolite profiles.
An effect on mortality has not been demonstrated and there are concerns regarding the long-term outcome of such interventions on microbial resistance in the community.
These models computationally can direct engineering interventions in microbial strains for targeted overproduction of chemicals [ 10- 13] and for elucidating the organizing principles of metabolism [ 14- 17].
However, the observed gut microbial alterations in both intervention groups did not support any consequences for energy harvest as indicated by unaltered faecal SCFAs.
Four studies provided strong evidence that the intervention changed microbial outcomes with low risk for alternative explanations, 8 studies provided less convincing evidence, and 4 studies provided no evidence.
Although our plasma 16S data did not indicate an effect of the synbiotic intervention on microbial translocation, it was of interest to explore whether in our cohort pretreatment levels of plasma 16S rDNA were related to pretreatment T-cell activation phenotypes as established by flow cytometry.
Defining gene targets within rumen methanogens for CH4 mitigation technologies is somewhat akin to developing a therapeutic intervention for a microbial pathogen, except that there are limitations in applying interventions to pasture-grazed ruminants.
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