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Wondering whether the enzymes were unique to Japanese individuals, Czjzek's team compared the microbial genomes of 13 Japanese people with those of 18 North Americans.
We describe a new in silico method for the prediction of bacterial pathogenicity, based on the identification in microbial genomes of features that appear to correlate with virulence.
The method proposed here seeks to identify features that are distinctive of virulence in microbial genomes of diverse species, and group them in "protein families".
The Pfam-based classifiers were trained with 21 (meta- genomes of biometa- genomess and 82 microfial genomes of non-degraders.
To date, we manage a total of 61 projects containing 117 newly sequenced microbial genomes (of which 77 from Genoscope).
It allows users to infer a multifurcating phylogenetic tree for any set of microbial genomes of interest to study their evolutionary relationships.
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Secondly, we constructed a mock-staggered community by randomly choosing 100 microbial genomes out of the 2,031 genomes in our dataset.
On the other hand, the notion that the human genome has co-evolved to its present state with this multitude of bacterial genomes, and that we require this symbiotic relationship for the maintenance of our health, suggests that the particular collection of microbial genomes each of us carries may be almost as personal as our own genome.
Furthermore, about 60% of the microbial genomes consisted of a single replicon – as is the case with KN400.
Increased understanding of lanthipeptide biosynthesis and accelerated sequencing of microbial genomes enabled characterization of lanthipeptides by genome mining of lanthionine synthetase genes.
We used the microbial genomes section of the Reference Sequence database (RefSeq, version as of Feb. 2009, 912 replicons) [ 32] to access a non-redundant collection of richly annotated chromosomes.
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