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Surprisingly, both the number of bacterial species as well as microbial gene richness decreased after dietary intervention.
In the Metagenomics of the Human Intestinal Tract (MetaHIT) study including 292 non-diabetic Danish individuals, 23% of the studied population sample had low microbial gene richness, with the bacterial gene count reduced by 40% [ 55].
Microbial gene richness was measured by counting the number of genes that are present for a given sample using a downsized count matrix as performed in the original studies.
Moreover, Cotillard et al. found that individuals with reduced microbial gene richness (40%%) presented with more pronounced dysmetabolism and low-grade inflammation than individuals with high bacterial gene richness [ 28].
Owing to progress in sequencing technologies, it is now possible to measure almost every microbial gene in the microbiome and even a simple measure such as counting the total number of genes (microbial gene richness) shows an intriguing relationship of this number with metabolic health.
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Indeed, obesity has been associated with altered gut microbiota composition, reduced microbial diversity, and reduced gene richness (Le Chatelier et al., 2013; Ley et al., 2005; Turnbaugh et al., 2009).
Recently the richness of gut microbial gene repertoire was proposed as a potential biomarker of the healthy microbiota: higher gene count was associated with better metabolic indicators.
This microbial gene pool comprises genes from hundreds of microbial species.
Detailed analyses of the resulting DGGE banding patterns revealed a rather limited chiA gene richness.
The resulting microbial gene profile was used for further analyses.
They call this amalgamation — human genes plus microbial genes — the metagenome.
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microbial gene content
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microbial gene transcription
microbial gene target
microbial gene regulation
microbial gene catalogue
microbial gene expression
microbial gene pool
microbial community richness
microbial gene presence
microbial gene evolution
microbial gene inventory
microbial gene family
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