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This microbial gene pool comprises genes from hundreds of microbial species.
Owing to the lack of exchange of genetic material with a global microbial gene pool, Mtb had long been considered to have a clonal population structure.
This suggests that genes encoding amylolytic, pore forming, enzymes were not widely present in the microbial gene pool, not even in the environment where granular starch is an abundantly available substrate.
There are three mechanisms through which the microbial gene pool may confer adaptation to the holobiont (Zilber-Rosenberg and Rosenberg 2008), (i) changes in microbial composition by differential proliferation within a host (ii) changes in microbial composition by acquisition of new symbiont types from outside and (iii) adaptation of microbial populations of the same species within hosts.
A 'closed' pan-genome is highly conserved, and is typical associated with bacterial species which live in select niches, where they are secluded from the overall microbial gene pool or have a diminished capacity to acquire genes, such as Bacillus anthracis and Mycobacterium tuberculosis [ 13, 14].
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However, it is estimated that due to the difficulties of isolation and culture, a gene pool of 99% of microbial diversity is unknown (4).
Beyond simply counting new species, metagenomics has also helped establish the link between the gene pool available to a microbial community and the environmental parameters that surround them.
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"They have a huge gene pool.
"I come from a good gene pool.
"It waters down the gene pool.
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microbial gene content
microbial gene transcription
microbial gene count
microbial gene target
microbial gene regulation
microbial gene catalogue
microbial gene expression
microbial gene presence
microbial gene evolution
microbial gene richness
microbial gene inventory
microbial biomass pool
microbial gene family
microbial consortium pool
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