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This shall provide the basis using FOXP3 methylation for in vivo microbial exposure in future field studies assessing childhood pulmonary diseases such as allergic asthma.
This trend is mainly limited to opportunistic or potentially pathogenic bacterial groups, and it is likely to reflect the microbial exposure in the shared living environment and/or the close contacts between family members, since most of the subjects in group F (13 out of 21, defined as group FC) lived with their centenarian parents.
The authors explained these results by a possible more diluted and thus lower microbial exposure in the outdoor environment.
Additional file 1: Detailed information about the selected home characteristics as possible predictors for microbial exposure in mattress dust.
As one of the leading candidates in the allergy epidemic, there has been a long-standing interest in the role of microbial exposure in early life.
For allergic diseases, some studies have suggested that the development of atopic diseases is facilitated by a decreasing level of microbial exposure in early life ("hygiene hypothesis) [ 15, 16].
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His main research interest is on the protective as well as adverse qualities of microbial exposures in the human living environment.
Since 2006 the author has focused his activities on public health related research on indoor microbial exposures in residential settings and in schools.
Early contact to environments rich in microbial exposures in farms and traditional rural settings may be protective.
Our exposure was based on clinically assessed measures of periodontal disease because these measures are manifestations of host response to adverse microbial exposures in dysbiotic periodontal biofilms.
A core concept in the hygiene hypothesis is that microbial exposures in early life may 'tune' immune responses and ensure host-immune homeostasis over the human lifetime.
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