Therefore, in the absence of microbial exposure, IgE isotype switch is fostered at mucosal sites, where microbially triggered immune adaptations, such as IgA isotype switch, normally take place.
No. Excessive use of cleaning and personal care products and antibacterials is sometimes said to be linked to allergies because it deprives us of microbial exposure.
The hygiene hypothesis has emerged, linking reduced microbial exposure and infections early in life with the development of allergic diseases.
Natural microbial exposure has been identified as an important environmental condition that provides asthma protection in a prenatal window of opportunity.
As societal change shifts our microbial exposure, concordant shifts in the tolerant and effector functions of our immune systems give rise to more hypersensitive responses to external antigens.
The major microbial exposure of individual mice is to the microbiota of other mice through contact such as coprophagy [39].
The rationale to use LpA-stimulation was to assess one "master stimulus" representing microbial exposure (TLR4-stimulation) as "protective stimulus" against allergy development.
This shall provide the basis using FOXP3 methylation for in vivo microbial exposure in future field studies assessing childhood pulmonary diseases such as allergic asthma.
We evaluated the microbial community in retropharyngeal lymph nodes of mule deer to assess microbial exposure via the oral or respiratory route.
Expression of SAAs is strongly induced by microbial exposure.
Is this reduced microbial exposure potentially detrimental to his health?
