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Chronic marginal periodontitis occurs worldwide and is among the most prevalent of microbial diseases in humans [ 7].
The need for new, effective and affordable drugs to treat microbial diseases in the developing world is one of the major issues facing global health today.
The need for new, effective and affordable drugs to treat microbial diseases in the developing world is one of the issues facing global health today.
Srinivasan and Ramasamy [ 25] detected 100% resistance to penicillin G in vibrios species associated with viral diseased shrimp in India and alert to the environmental, economic, and management problems that may result from the emergence of drug resistant microbial diseases in aquaculture.
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Finally, our results suggest that growth-related changes in cell wall protein expression, as well as stress/virulence-related changes in the topology of surface protein presentation, may dynamically modulate the ability of this organism to interact with and recruit plasminogen and possibly other plasma-derived mammalian factors implicated in the progression of microbial disease, in vivo.
Streptococcus pneumoniae is an important cause of microbial disease in humans.
We describe a series of 56 isolates submitted to California's Microbial Diseases Laboratory (MDL) in a 32-year period with laboratory and epidemiologic factors associated with these infections.
coli) pyruvate dehydrogenase multienzyme complex E1 (PDHc E1), a series of novel 'open-chain' classes of ThDP analogs A, B, and C with N-acylhydrazone moieties was designed and synthesized to explore their activities against E. coli PHDc E1 in vitro and their inhibitory activity against microbial diseases were further evaluated in vivo.
Adhesion constitutes one of the initial stages of infection in microbial diseases and is mediated by adhesins.
This project was supported by the NIHR Biomedical Research Centre in Microbial Diseases, Liverpool.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2466/14/25/prepub This work received financial support from The Bill and Melinda Gates Foundation (Grand Challenge Exploration programme), the National Institute of Health Research NIHRR) and the Biomedical Research Centre (BRC) in Microbial Diseases.
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