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Ever since the germ theory of disease was validated by Koch in the late nineteenth century, our understanding of microbial diseases has been largely governed by the one pathogen/one disease paradigm until very recently when technical advances made it possible to scrutinize the entire microbial community (or microbiome) on all external (skin) and internal (mucosal) surfaces of our body.
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Vaccines against microbial diseases have improved the health of millions of people.
Many mechanisms involved in the cross-talk between innate receptors which are involved in poly-microbial diseases have not been fully characterized.
While the IEMs modeled in this study are individually rare and to our knowledge, the effects of gut microbial activity on the disease phenotype have not been studied, the etiology of common diseases, such as obesity, inflammatory bowel disease, and circulatory diseases, has been directly linked to the gut microbiota.
The concepts of microbial etiology and pathogenesis of infectious diseases have undergone revisions since the pioneer researcher of microbial diseases, Robert Koch, postulated the criteria for microbial etiology of diseases.
Microbial pathogenecity and other infectious diseases have been controlled by use of commercially available antimicrobial drugs since last many years.
Microbial diseases of plants have been inadvertently spread around the world by human activities.
To date, several human diseases have been significantly correlated with dysbiosis of specific microbial communities [ 6– 9].
Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis.
Crohn's disease has long been known to be associated with microbial communities in the intestine, but the exact etiology has been unclear.
Despite an abundance of data on incidence, prevalence and density of potential pathogens in NP microbiota of children and adults, the detailed composition of the NP microbial community, both during health and disease have not been studied.
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