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Different hydroxylated and epoxidated epothilone A have been produced by microbial biotransformation using Aspergillus niger (Wang et al. [2009]) which were characterized by different NMR analyses.
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The first attempts of biotransformation using expressed nitrilases from several bacterial strains were unsatisfying.
Microbial biotransformation has been used for the production of shikimic acid from quinic acid in recent few years as a potent alternative of the available methods [16],[16].
Biotransformations using enzymes and whole microbial cells have been used for centuries to produce foods and beverages.
From quinic acid, it is converted to shikimate by three enzymatic steps using microbial biotransformation [19].
Biotransformations, using plant cells and isolated enzymes, have an immense potential in the production of pharmaceuticals.
Considerable progress has been made in manipulating oxidative biotransformations using oxygenases.
Biotransformations using whole cells and enzyme-catalyzed reactions have been attempted for the production of various chiral compounds.
The main biological strategies that have been used to achieve flavonoid glycosylation in the laboratory involve metabolic pathway engineering and microbial biotransformation.
It is a rule-based system currently encompassing 249 microbial biotransformation rules based on over 1350 microbial catabolic reactions and about 200 biodegradation pathways.
In continuation of our recent work on the microbial transformation of important steroids [2], we investigated the microbial biotransformation of DHT.
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