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This study provides a potential approach for the production of bacillamide C and related derivatives, which was the first to optimize the cultivation of sponge-associated microbes for the production of marine natural products.
We argue that a systematic approach consisting of fine-tuning the properties of individual pathway components, prominently enzymes, is a superior strategy to searches spanning large genetic spaces in engineering optimal microbes for the production of chemical and pharmaceutical products.
Therefore, the present review has been focused on thermophilic/thermotolerant microbes for the production of ethanol, especially on their catabolic pathways, end-product formation and their future perspectives for industrial applications.
Engineering biosynthetic pathways in microbes for the production of complex chemicals and pharmaceuticals is an attractive alternative to chemical synthesis.
In the last two years, significant progress has been made in engineering microbes for the production of adipic acid and its immediate precursors, muconic acid and glucaric acid.
Engineering microbes for the production of hormones and immunological agents has also been described.
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Bacillus amyloliquefaciens is an important industrial microbe for the production of many industrial enzymes and primary metabolites.
Although clostridia are the primary industrial microbes for the fermentative production of 1-butanol, alternative engineered hosts have the potential to generate 1-butanol from alternative carbon feedstocks via synthetic metabolic pathways.
Nowadays, microbes are employed for the production of a wide array of complex drug molecules or precursors (Chen and Nielsen 2013; Nielsen et al. 2014), such as biofuel molecule (Rabinovitch-Deere et al. 2013), limonene and perillyl alcohol (Alonso-Gutierrez et al. 2013), terpenoids (Gupta et al. 2015; Wang et al. 2016), l-methionine (Huang et al. 2016).
Corynebacterium glutamicum is an industrial microbe traditionally used for the production of amino acids.
Metabolic engineering of microbes has been successfully used for the production of a variety of useful compounds in microbes (Keasling, 2010; Shimizu, 2002; Stephanopoulos et al., 1998; Zaldivar et al., 2001).
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