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Similar profiles of DNA replication timing have been generated using microarrays that monitor DNA copy number increase without enrichment of nascent DNA in S. cerevisiae and Drosophila melanogaster [5], [6].
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Sequences that map back to the same genetic locus may actually be given different names and descriptions when they are deposited in public sequence databases; when such sequences are used in microarray construction, elements that monitor the same genetic locus may have different names and descriptions.
The capabilities of microarray technology are further expanding with the development of label-free optical techniques that monitor the real-time dynamics of biomolecular interactions.
Q. ARE YOU USING THE SAME TECHNOLOGY TO STUDY MALARIA? A. Yes, we use DNA microarrays that are similar to the virus chips.
There are also entirely new approaches, like genetic microarrays that detect precancerous genes in breast tissue; identification of tumor markers -- proteins that appear on the surface of some cells; and blood tests that might detect secretions from cancerous cells.
"Oh, that monitor?
Recently, with the emergency of microarray technology that can monitor thousands of genes simultaneously, gene biomarkers are being detected for oral cancers.
However, presently there are only a few papers on activation-dependent genome-wide alternative splicing in human T lymphocytes, using the Agilent 44K microarray platform that allows monitoring of >5000 cassette-type AS events in human cells [28], as well as Exon 1.0 ST array to study the genome-wide effect of silencing a splicing factor during T cell activation [48].
falciparum) and a reference species (for example S. cerevisiae), (2) two microarray data sets that monitor the level of expression of the genes of the two species, and (3) a set of likely orthologs between the two species.
In order to monitor the transcriptional changes that occur during T. rubrum conidial germination, we assembled an expression microarray that consists of 10250 ESTs.
Microarrays that permit simultaneous monitoring of expression of many genes provide a more global overview of how genes work together to control seed metabolism.
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