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The microarrays revealed not only very detailed specificity profiles for all the binders, but also showed that overlapping target sequences of spotted antigens were detected by off-target interactions.
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The use of microarrays revealed reproducible transcriptomic markers that were common to the various treatments as well as markers that were specifically representative of each of the treatments, while TEWL measurements could not reveal differences between the treatments.
They reveal — not much.
Additionally, microarray revealed a paternally inherited Xq21.1 duplication.
Thus, microarrays can reveal binding sites not apparent from secondary structure prediction or from enzymatic/chemical mapping.
Here we found that eukaryotic elongation factor-2 (eEF-2) was dramatically dephosphorylated within 0.5 2 hr in the hippocampus and amygdala of mice following training in a fear-conditioning test, whereas genome-wide microarrays did not reveal any significant change in the expression level of the mRNAs for translational machineries or their related molecules.
Microarray analysis revealed that this was not due to expression changes within the sulfate assimilation pathway, which is known to be a major contributor to H2S production.
While the phenotype microarray did not reveal a distinct pattern of mutation among the archival isolates, the data did confirm that various isolates have used multiple strategies to survive in the archival environment.
Focal amplification of the MET gene, however, is not a common finding in human breast cancer: interphase fluorescence in situ hybridization performed on a human breast cancer tissue microarray did not reveal any amplification of the Met genomic locus [ 65], and this genetic alteration has not so far been reported for BRCA1 mutation carriers.
Significance Analysis of Microarrays (SAM) revealed no sex bias in gene expression from the microarray data.
Microarray analysis also revealed PLXDC2, but not PLXDC1, as one of the markers of adult stem cells (Noh, 2006).
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