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Using oligonucleotide microarrays in primary human CD34+ cells, a group of genes was identified whose dysregulation by NUP98-HOXA9 is attributable primarily to the NUP98 portion.
Gene expression, cytosine methylation and histone H3 lysine 9 (H3K9) acetylation were measured using high-density oligonucleotide microarrays in primary human acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) specimens.
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18 miRNAs, including 6 up-regulated and 12 down-regulated miRNAs were identified by microarray in primary HCC samples of patients who had developed HCC recurrence (n = 5) compared to those with non-recurrence (n = 5) following OLT by using p < 0.05 as cutoff value.
Second, cDNA expression microarray in primary melanoma has revealed a signature of 254 genes characterising patients at risk of developing distant metastases (Winnepenninckx et al, 2006).
Perhaps the most exciting potential of miRNAs in current diagnostics started with a study comparing miRNA expression using miRNA microarrays in 205 primary versus 131 metastatic tumors covering 22 different tumor origins.
The expression profiles of genes and microRNAs, regulated by the treatment of SST, were measured by using microarray analysis in primary mouse hepatocytes.
In a previous work it has been shown by microarray analysis in primary HPV16 and HPV18-infected cervical cancers and normal cervical epithelium similar results for genes related to cell cycle control [ 49].
The van 't Veer study used DNA microarray analysis in primary breast tumors, and "applied supervised classification to identify gene expression signature strongly predictive of a short interval to distant metastases ('poor prognosis' signature) in patients without tumor cells in local lymph nodes at diagnosis (lymph node negative)".
It should also be noted that in two microarray studies performed in primary breast-tumor samples before and after 24 72 h after chemotherapy, the up-regulated number of genes is ca 20% of those observed in our study [57], [58].
EXPERIMENTAL DESIGN: CD3+, CD4+, CD8+ TILs and MHC1, 2 expression were evaluated by immunohistochemistry on tissue microarrays in 113 paired primary and recurrent HGSOC.
Breast tissue microarray analysis showed NR4A1 expression in primary tumours, which was reduced in higher grade and metastatic tumours.
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