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The G. holbrooki microarray will allow for this non-model species to become more fully developed into a bioindicator organism for endocrine disrupting pollutants and future studies will enhance knowledge of the biology and toxicological response of this species.
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In the future, the availability of microarrays will allow us to investigate such differences in adaptation strategies at the functional genomics level.
We hope that the increased capability of the recently available, more powerful 100K and 300K microarray platforms will allow the inclusion of probes complementary to common insertions and deletions at each sequence position to overcome this technological limitation.
Microarray analysis will allow us to study genetic contribution and patterns of altered gene expression related to T2D.
Microarray experiments will allow association of gene expression changes with polyphenism, the development for morphologically different individuals (e.g. winged and unwinged) that are otherwise genetically identical.
With respect to future frontiers in array-based platforms, the development of a triple microarray that will allow highly sensitive analysis of disease-related changes in DNA methylation, histone modifications, and microRNA expression simultaneously will provide new insights for more comprehensive epigenetic biomarker development.
Our EST catalogue could provide a source for the design of microarray platform that will allow the study of the transcriptional responses of this abundant marine organism to environmental challenges [ 39].
Finally, the production of a much larger SPAD plus TDC array will allow 256 microarray spots to be measured in a single detection event, opening true opportunities for high throughput FLIM detection.
Ultimately, however, linking microfluidic-microarray devices with sophisticated bioinformatics will allow for longitudinal and cross-sectional studies of the microbiota and human health that until now were inconceivable.
A C. gattii serotype B microarray has now become available [33] and will allow gene expression in C. gattii strains to be studied directly.
Among other interests, this resource will allow large scale expression profiling experiments using microarrays based on a well characterized cDNA clone collection.
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