We used microarray technology in a trophoblast cell line to identify hypoxia-responsive genes that may impact placentation.
To identify novel factors produced in the asthmatic airway, we analyzed sputum samples by using a membrane-based human cytokine microarray technology in patients with bronchial asthma (BA).
In this work we tackled this 'double blind' problem by exploiting the high-throughput capacity of carbohydrate microarray technology, in particular the Comprehensive Microarray Polymer Profiling (CoMPP) method, which has been successfully applied to streptophyte systems21,22.
In this study, we assessed whether the current generation of microarray technology in combination with an in vitro experimental design was capable of generating robust, reproducible data of sufficient quality to show promise as a tool for regulatory risk assessment.
Besides the design and generation of microarrays as well as their use in hybridization experiments and subsequent data analysis, recent applications of DNA microarray technology in C. glutamicum including the characterization of ribose-specific gene expression and the valine stress response will be described.
The most common application of microarray technology in disease research is to identify genes differentially expressed in disease versus normal tissues.
Thus, we selected it to represent microarray technology in our analysis.
Therefore, this study confirms the aptitude of microarray technology in defining molecular pathways involved in MM pathogenesis and progression.
Promising as it is, there are concerns regarding the reliability, and hence the utility, of DNA microarray technology in the study of physiological processes and diseases [5], [6].
In a review article, Shendure, described that the next-generation high throughput sequencer would replace DNA microarray technology in the transcriptome research field [20].
The goal of our study was the molecular dissection of MM tumour pathways by mean of microarray technology in order to identify new tumour biomarkers, which could be used as early diagnostic markers or as new specific therapeutic targets.
