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4. The approach follows the selection criterion of robustness, i.e. technical noise in measured mRNA concentrations caused by the microarray technology does not alter inferred regulatory interactions.
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So we do believe our work, by involving not only 4 different microarray platforms, but more importantly also a deep sequencing technology, does yield new knowledge.
But technology doesn't wait.
Technology does not run backward.
Old technology doesn't sell.
Sometimes technology does not work.
Technology: Do QR Codes Work?
A limitation of microarray technology is that it does not provide data on possible protein level changes.
Our analysis showed that the microarray and MPSS technologies did not correlate well on a quantitative basis for transcript abundance measurements, although within-technology clustering of samples was largely consistent.
With the vast amount of work still to be done, microarray technology will have an increasingly important role in the post-genomic era and will most certainly be an essential player in the post-genomic era.
This was done by applying microarray technology on multiple synovial biopsies obtained from the same knee joints.
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